HOW COULD OBESITY LEAD TO CANCER?

Fat (also known as adipose tissue) has two main roles in the body. It exists to store calories in the form of chemicals called lipids, and a huge gland, sending out a constant stream of biological information and instructions that affect the rest of your body. This helps control processes like growth, metabolism and reproductive cycles. But because of their ability to turn biological processes on and off, the signals produced by fat have a darker side when it comes to cancer.

1. The oestrogen connection

One of the strongest links between obesity and cancer is an increased risk of breast and womb cancers in women who are overweight or obese after the menopause, and this relates to higher oestrogen levels. Large studies of women have shown a direct relationship between obesity, high oestrogen levels and breast and womb cancers and understanding this relationship has been critical in developing effective treatments – like tamoxifen and aromatase inhibitors – that work by cutting off oestrogen.

2. Metabolic chaos

The chemical processes going on constantly throughout the body – collectively known as metabolism – are complicated and tightly controlled, relying on a finely tuned web of information flowing between cells and organs. But the chemical signals produced by fat cells means that obesity can cause a major upset to this balance, and this is thought to be another way it makes cancer more likely.

One key hormone that acts as a master-controller of metabolism is insulin. It’s made by the pancreas and orchestrates how cells take up and process glucose from the blood.

Large studies of peoples’ blood chemistry have also shown links between high glucose (even at levels below those needed for a diagnosis of diabetes) and the risk of several types of cancer.

3. Inflammation

As people become obese, and more fat cells build up in their tissues, specialized immune cells (called macrophages) are called to the scene, possibly to clear up dead and dying fat cells. But as macrophages carry out their clean up job, they also release a potent cocktail of chemicals called cytokines that summon other cells to help them out. The number of macrophages in obese fatty tissue can be substantial – they can account for as many as four in 10 cells.

This ultimately creates a condition called chronic inflammation. The result of inflammation is a cocktail of signals that tell cells to divide, because after injury you need new cells for healing to occur. But the signals encouraging cell growth for healing can also support cancer cells dividing. In fact if we look at the genes that are turned on and off in inflamed tissue, it’s very similar to genetic changes we see in cancer cells.

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WHY ARE MORE MEN THAN WOMEN LIKELY TO DIE OF CANCER?

The American Cancer Society's comprehensive annual report on cancer incidence, mortality, and survival. It is published in CA: A Cancer Journal for Clinicians and is accompanied by a consumer version of the publication, Cancer Facts and Figures 2017. The report estimates that in 2017, there will be higher cancer incidence and mortality rate in men than women.

The report finds significant gender disparities in incidence rate of 20% higher in men than in women, while the cancer death rate is 40% higher in men.

The gender gap in cancer mortality largely reflects disparity in the distribution of cancers that occur in men and women, much of which is due to differences in the prevalence of cancer risk factors.

For example, liver cancer, a highly fatal cancer, is three times more common in men than in women, partly reflecting higher Hepatitis C/B virus infection, historical smoking prevalence, and excess alcohol consumption in men. The largest sex disparities are for cancers of the oesophagus, larynx, and bladder, for which incidence and death rates are about 4times higher in men. Melanoma incidence rates are about 60% higher in men than in women, while melanoma death rates are more than double in men compared to women.

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NEW STUDY LINKED ASTHMA SEVERITY TO BLACKS

Asthma a respiratory condition marked by attacks of spasm in the bronchi of the lungs, causing difficulty in breathing. It is usually connected to allergic reaction or other forms of hypersensitivity.

Airway inflammation is major part of asthma, and advancement in treatment are becoming more individualized based on the specific type of airway inflammation in a patient. Differences in airway inflammation can affect a patient's response to treatment, but whether the patterns of airway inflammation differ across race has, until now, been very unclear.

Black men and women are two to three times more likely than whites to be hospitalized or die from asthma. And while many factors contribute to the burden of asthma in African Americans -- such as access to health care and environmental exposures -- rates are disproportionate even when social and environmental elements are taken into account.

African Americans may be less responsive to asthma treatment and more likely to die from the condition, in part, because they have a unique type of airway inflammation, according to a recent study. 

The study is one of the largest and most diverse trials conducted in the U.S. on race and asthma, with 26 percent of the patients identified as African American. Researchers found that black patients were more likely to exhibit eosinophilic airway inflammation than whites, despite taking comparable doses of asthma medication, such as inhaled corticosteroids. The results are published in the Journal of Allergy and Clinical Immunology.

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OBESITY-ASSOCIATED PROTEIN LINKED TO LEUKEMIA DEVELOPMENT

Cancer researchers at the University of Cincinnati (UC) College of Medicine have found an obesity-associated protein’s role in leukaemia development and drug response which could lead to more effective therapies for the illness.

The study, published in the online edition of Cancer Cell  provided evidence that FTO -- the protein associated with fat mass and obesity -- plays a critical cancer-promoting role by regulating expression of a set of genes through a mechanism involving ribonucleic acid (RNA) modification and thereby increasing the reproduction of leukaemia cells and prohibiting drug response.

Researchers in the study analyzed a microarray dataset of 100 human acute myeloid leukaemia (AML) samples from patients and nine normal control samples as well as other large-scale microarray datasets of AML samples. They found that FTO was highly expressed in various subtypes of leukaemia samples such as those that contained chromosome crossover (genetic exchange between chromosomes) or mutations in certain genes. The high level of FTO expression contributed to cancer cells multiplying and surviving and also promoted the development of leukemia in animal models and the non-response of cancer cells to therapeutic agents.

Additionally, researchers found that genes like ASB2 and RARA, which were reported to inhibit leukaemia cell growth and/or mediate the response of leukaemia cells to therapeutic agents, were suppressed in the AML samples with higher FTO expression. The suppression of these genes was attributed to FTO-controlled decreased stability of their mRNA and was connected to FTO's m6A demethylase activity.

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GESTATIONAL DIABETES LINKED WITH IRON LEVEL

High levels of iron are linked with a higher risk of developing gestational diabetes (GDM), which calls into question routine recommendations for iron supplements for pregnant women, new research indicates.

Results from a study published in Diabetologia on November 10 showed that women who were in the top quartile for iron biomarkers in the second trimester of pregnancy had about 2.5 times the risk of developing GDM compared with those in the bottom quartile.

The researcher thinks that is more likely that iron supplements are a contributor to gestational diabetes, rather than the cause of it, pregnant women should be screened for iron levels and given supplements only if they are deficient.

Too much iron as well as too little can cause harm, and pregnant women are often susceptible to low iron levels and related adverse outcomes. 

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INFLAMMATION AND DIABETES COMPLICATIONS: ANY LINK?

Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, the body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood.

Over time, having too much glucose in blood can cause serious problems. It can damage your eyes, kidneys, and nerves. Diabetes can also cause heart disease, stroke and even the need to remove a limb.

The number of people with diabetes has quadrupled worldwide over the last 20 years.

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers have discovered, in mice, that when certain immune cells can’t manufacture fat, the mice don’t develop diabetes and inflammation, even when consuming a high-fat diet.

But eliminating inflammation altogether is not the answer to preventing diabetic complications because inflammation is also vital for clearing infectious pathogens from the body and helps wounds heal. Still, Semenkovich said the new findings may have profound clinical implications.

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ARE YOU AT RISK OF OTHER SYMPTOMS OF BREAST CANCER ?

Around one in six women (17 per cent) diagnosed with breast cancer goes to her doctor with a symptom other than a lump -- the most commonly reported breast cancer symptom, according to new research presented at the 2016 National Cancer Research Institute (NCRI) Cancer conference in Liverpool.

Breast symptoms, other than a breast lump, that may be a sign of cancer (termed 'non-lump' in the study) include nipple abnormalities, breast pain, skin abnormalities, ulceration, shape abnormalities and an infected or inflamed breast.

Researchers from UCL examined the data of more than 2,300 women diagnosed with breast cancer in England in 2009/10. They found that, although most women with breast cancer sought help quickly, those with 'non-lump' symptoms were more likely to delay going to their doctor compared with women with a breast lump alone.

Women with both a breast lump and 'non-lump' symptoms were also more likely to delay seeking help.

Women presenting with breast ulceration, nipple abnormalities, breast infection or inflammation, swollen arm or armpit, and pain in the armpit were more likely to wait longer than three months to seek help.

It's crucial that women are aware that a lump is not the only symptom of breast cancer. If they are worried about any breast symptoms, the best thing to do is to get it checked by a doctor as soon as possible. Diagnosing cancer earlier really is key in order to increase the chances of survival. Symptom awareness campaigns such as the Be Clear on Cancer campaign should continue to emphasise breast symptoms other than breast lump. 

Source: Science Daily

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